Duck S W, McConnel F M
St Joseph Hospital, Atlanta, GA.
Am J Otolaryngol. 1993 May-Jun;14(3):175-8. doi: 10.1016/0196-0709(93)90026-4.
The incidence of carcinoma arising in a pleomorphic adenoma is reportedly between 1.4% and 6.3%. Malignant degeneration is often associated with a prolonged history of untreated or recurrent pleomorphic adenoma.
Two patients with malignant parotid carcinoma that arose from benign pleomorphic adenoma are reviewed.
Both patients exhibited a prolonged history of pleomorphic adenoma apparently persistent after initial inadequate surgery. Surgeries were performed 37 and 12 years before development of malignancy.
The phenomenon of malignant carcinoma arising from benign pleomorphic adenoma is an important issue. The occurrence of these malignant carcinomas emphasizes that aggressive treatment of primary and recurrent mixed tumors is necessary.
据报道，多形性腺瘤中发生癌的发生率在1.4%至6.3%之间。恶性变常与未经治疗或复发性多形性腺瘤的病史延长有关。
回顾了2例由良性多形性腺瘤发生的腮腺恶性癌患者。
两名患者均有多形性腺瘤病史延长，在初次手术不充分后明显持续存在。在发生恶性肿瘤前37年和12年进行了手术。
良性多形性腺瘤发生恶性癌的现象是一个重要问题。这些恶性癌的发生强调了对原发性和复发性混合瘤进行积极治疗的必要性。
