牛嗜铬细胞拥有对FTX敏感的钙通道。
Bovine chromaffin cells possess FTX-sensitive calcium channels.
作者信息
Gandía L, Albillos A, García A G
机构信息
Departamento de Fisiología y Farmacología, Universidad de Salamanca, Spain.
出版信息
Biochem Biophys Res Commun. 1993 Jul 30;194(2):671-6. doi: 10.1006/bbrc.1993.1874.
The effects of the synthetic analogue of the toxin from the venom of the funnel-web spider Agenelopsis aperta (sFTX) on whole-cell Ba2+ currents through Ca2+ channels were studied in cultured bovine chromaffin cells. sFTX selectively and reversibly blocked a significant component (55 +/- 3%) of the whole-cell IBa. Effects of sFTX were additive to those of omega-conotoxin GVIA, a selective blocker of N-type Ca2+ channels, and those of furnidipine, a novel dihydropyridine L-type Ca2+ channel blocker. We conclude that the cultured bovine chromaffin cells, in addition to N- and L-type Ca2+ channels, possess a P-type component in their whole-cell currents through their Ca2+ channels.
在培养的牛嗜铬细胞中研究了漏斗网蜘蛛Agenelopsis aperta毒液毒素的合成类似物（sFTX）对通过Ca2+通道的全细胞Ba2+电流的影响。sFTX选择性且可逆地阻断了全细胞IBa的一个重要成分（55±3%）。sFTX的作用与ω-芋螺毒素GVIA（一种N型Ca2+通道的选择性阻断剂）以及新型二氢吡啶L型Ca2+通道阻断剂福尼地平的作用具有加和性。我们得出结论，培养的牛嗜铬细胞除了具有N型和L型Ca2+通道外，其通过Ca2+通道的全细胞电流中还存在一个P型成分。
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