Cohen L F, di Sant'Agnese P A, Taylor A, Gill J R
J Pediatr. 1977 Apr;90(4):574-8. doi: 10.1016/s0022-3476(77)80369-7.
The syndrome of inappropriate secretion of antidiuretic hormone was observed in two patients with cystic fibrosis during acute exacerbation of chronic pulmonary disease. It was diagnosed by the accepted clinical and laboratory criteria and confirmed in one case by values for immunoreactive vasopressin that were inappropriately high for plasma osmolality. The severe hyponatremia was corrected by fluid restriction, alone or combined with intravenous treatment with diuretic and hypertonic saline solution. In addition, there was simultaneous therapy of the pulmonary disease. SIADH thus must be added to salt loss as a cause of hyponatremia in CF, and may be more common than realized in patients with CF and severe pulmonary disease.
在两名患有囊性纤维化的患者慢性肺部疾病急性加重期观察到抗利尿激素分泌不当综合征。通过公认的临床和实验室标准进行诊断，在一例中通过免疫反应性血管加压素的值得到证实，该值相对于血浆渗透压而言过高。通过限制液体摄入，单独或联合使用利尿剂和高渗盐溶液进行静脉治疗来纠正严重的低钠血症。此外，同时对肺部疾病进行治疗。因此，在囊性纤维化中，抗利尿激素分泌不当综合征必须作为低钠血症的一个原因添加到盐丢失中，并且在患有囊性纤维化和严重肺部疾病的患者中可能比认识到的更常见。
