Vinay L, Grillner S
Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm, Sweden.
Neuroreport. 1993 Jun;4(6):609-12. doi: 10.1097/00001756-199306000-00001.
Lamprey spino-bulbar neurones modulate the activity of reticulospinal cells during locomotion. The aim of the present study was to investigate the effects of interrupting or increasing this feedback from the spinal cord on the fictive locomotor pattern. Double-bath experiments were performed on in vitro brain stem/spinal cord preparations. Fictive locomotion was induced by perfusing the spinal cord with 150 microM N-methyl-D-aspartate (NMDA). Blocking the synaptic transmission in the brain stem by exposing it to Mn2+ ions increased the locomotor rhythm. Conversely, stimulation of single reticulospinal neurones during the ipsilateral ventral root burst, when they were depolarized, increased the cycle duration by prolonging the ipsilateral motor burst. The spino-reticulo-spinal loop is an integral part of the locomotor network.
七鳃鳗的脊髓-延髓神经元在运动过程中调节网状脊髓细胞的活动。本研究的目的是探讨中断或增强来自脊髓的这种反馈对虚拟运动模式的影响。在体外脑干/脊髓标本上进行了双浴实验。通过用150微摩尔/升的N-甲基-D-天冬氨酸（NMDA）灌注脊髓来诱导虚拟运动。将脑干暴露于锰离子中阻断其突触传递会增加运动节律。相反，在同侧腹根爆发期间，当单个网状脊髓神经元去极化时对其进行刺激，会通过延长同侧运动爆发来增加周期持续时间。脊髓-网状-脊髓环路是运动网络的一个组成部分。
