Ghirardi P, Catenazzo G, Mantero O, Merotti G C, Marzo A
J Pharm Sci. 1977 Feb;66(2):267-9. doi: 10.1002/jps.2600660233.
The in vitro dissolution and the bioavailability of two pharmaceutical formulations of digoxin were compared, one being a common commercial tablet form and the other a solution of the glycoside in soft gelatin capsules. Digoxin capsules dissolved more readily in vitro and showed higher bioavailability than digoxin tablets in both dogs and humans. In dogs, the capsules and tablets were compared with an elixir of digoxin, which possesses complete bioavailability. The better bioavailability of digoxin capsules as compared with tablets may be explained by the fact that this formulation contains the cardiac glycoside in a solution.
比较了地高辛两种药物制剂的体外溶出度和生物利用度，一种是常见的市售片剂形式，另一种是糖苷在软胶囊中的溶液。地高辛胶囊在体外更容易溶解，并且在犬和人类中均显示出比地高辛片剂更高的生物利用度。在犬中，将胶囊和片剂与具有完全生物利用度的地高辛酏剂进行了比较。与片剂相比，地高辛胶囊具有更好的生物利用度，这可能是因为该制剂中的心苷处于溶液状态。
