Li J, Zhao Y N, Miao Z J, Zhu L, Wang Z M, Qin H Y, Xi J H
Department of Obstetrics and Gynecology, Changhai Hospital, Shanghai, People's Republic of China.
Gynecol Oncol. 1993 Jul;50(1):10-4. doi: 10.1006/gyno.1993.1155.
Tissue tolerance to pelvic intraarterial chemoembolization with cisplatin-lipiodol suspension was studied in rabbits. Cisplatin (3 mg/kg) was used with different doses of lipiodol (0.0, 0.1, 0.2, and 0.3 ml/kg). Cisplatin-lipiodol suspension was injected into the umbilical artery through a long polyethylene catheter. Local tissue concentration of platinum was increased with lipiodol, while that in the liver, heart, and kidneys was reduced. Tissue retention of platinum was linearly related to the dosage of lipiodol. With a single dose of 0.2 ml/kg lipiodol, only slight degeneration and sparse hemorrhage were observed without necrosis.
在兔身上研究了组织对顺铂-碘油混悬液盆腔动脉内化疗栓塞的耐受性。顺铂（3mg/kg）与不同剂量的碘油（0.0、0.1、0.2和0.3ml/kg）联合使用。通过一根长的聚乙烯导管将顺铂-碘油混悬液注入脐动脉。铂的局部组织浓度随碘油增加，而在肝脏、心脏和肾脏中的浓度降低。铂的组织潴留与碘油剂量呈线性相关。单次给予0.2ml/kg碘油时，仅观察到轻微变性和少量出血，无坏死。
