Phase II study of trimetrexate in previously untreated patients with hepatocellular carcinoma. Southwest Oncology Group study 8712.

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超能文献

作者信息

Harvey W H, Fleming T R, Goodman P J, Harvey J H, Rivkin S E, MacDonald J S

机构信息

Associates in Hematology and Oncology, Fort Myers, FL.

出版信息

Invest New Drugs. 1993 Feb;11(1):45-6. doi: 10.1007/BF00873909.

DOI:10.1007/BF00873909

PMID:8394295

Abstract

摘要

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本文引用的文献

Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.三甲曲沙（TMQ，2,4-二氨基-5-甲基-6-[(3,4,5-三甲氧基苯胺基)甲基]喹唑啉）在耐甲氨蝶呤白血病细胞中的体外摄取及疗效，一种非经典抗叶酸剂

Biochem Pharmacol. 1984 May 15;33(10):1697-9. doi: 10.1016/0006-2952(84)90298-3.

Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.对甲氨蝶呤耐药的人淋巴瘤和骨肉瘤细胞中对抗叶酸药物三甲曲沙、美托普林、高叶酸和CB3717的交叉耐药模式。

Cancer Res. 1983 Nov;43(11):5286-92.

Pharmacokinetics of trimetrexate (NSC 352122) in monkeys.三甲曲沙（NSC 352122）在猴子体内的药代动力学。

Cancer Res. 1986 Jan;46(1):169-74.

2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor--I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo.

Biochem Pharmacol. 1979 Jun 15;28(12):1983-7. doi: 10.1016/0006-2952(79)90655-5.

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