Speiser P, Zeillinger R, Wiltschke C, Sedlák J, Chorváth B
1st Department of Obstetrics and Gynecology, University Hospital, Vienna, Austria.
Neoplasma. 1993;40(3):137-40.
The IL-1 alpha induced up-regulation of HLA class I and HLA class II (DR) antigen expression on the cell surface of the human breast cancer cell line ZR-75-1 was demonstrated. This was associated with a concomitant increase in TNF alpha production. Coincubation with an anti-TNF alpha neutralizing antibody partially inhibited the IL-1 alpha induced up-regulation of HLA DR antigen but had no effect on IL-1 alpha induced HLA class I up-regulation. These data indicate that IL-1 alpha induced HLA class II (DR) antigen up-regulation in ZR-75-1 cells is partially mediated by TNF alpha and that IL-1 alpha induced HLA class I and class II (DR) antigen up-regulation in ZR-75-1 human breast cancer cells in vitro are mediated by different mechanisms.
已证实白细胞介素-1α（IL-1α）可诱导人乳腺癌细胞系ZR-75-1细胞表面的I类和II类（DR）人白细胞抗原（HLA）表达上调。这与肿瘤坏死因子α（TNFα）产生的同时增加相关。与抗TNFα中和抗体共同孵育可部分抑制IL-1α诱导的HLA DR抗原上调，但对IL-1α诱导的I类HLA上调无影响。这些数据表明，IL-1α诱导ZR-75-1细胞中II类（DR）HLA抗原上调部分由TNFα介导，且IL-1α在体外诱导ZR-75-1人乳腺癌细胞中I类和II类（DR）HLA抗原上调是由不同机制介导的。
