Tonami N, Yokoyama K, Shuke N, Taki J, Kinuya S, Miyauchi T, Michigishi T, Aburano T, Hisada K, Watanabe Y
Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan.
Nucl Med Commun. 1993 Jul;14(7):602-10. doi: 10.1097/00006231-199307000-00014.
201Tl single photon emission computed tomography (SPECT) was evaluated in 170 patients suspected of having a malignant pulmonary lesion greater than 20 mm in diameter on the surgical specimen. Delayed SPECT (at 3 h after injection) visualized all of the 147 malignant pulmonary lesions and 16 of the 23 (69.6%) benign pulmonary lesions, and generally exhibited the lesion more clearly than the early SPECT images (at 15 min after injection). There was no significant difference in delayed ratio (uptake ratio of the lesion to the normal lung on delayed scan) among the various histological groups except between the adenocarcinoma and large cell carcinoma groups (P < 0.05), and no difference was noted between the malignant and benign lesions. However, in retention index (degree of retention in the lesion) a significant difference was noted between the malignant and benign lesions (P < 0.01), although there was no significant difference in this index among malignant different histology groups. These results indicate that this method is useful for visualizing malignant pulmonary lesions greater than 20 mm in diameter to exclude the possibility of malignancy in the lesions when no abnormal 201Tl accumulation is observed. When the lesion shows abnormal 201Tl accumulation, the retention index seems to help differentiate malignant from benign lesions.
对170例手术标本直径大于20 mm、疑似患有恶性肺病变的患者进行了201铊单光子发射计算机断层扫描（SPECT）评估。延迟SPECT（注射后3小时）显示了所有147例恶性肺病变以及23例良性肺病变中的16例（69.6%），并且一般比早期SPECT图像（注射后15分钟）更清晰地显示病变。除腺癌组和大细胞癌组之间外（P<0.05），各组织学组的延迟率（延迟扫描时病变与正常肺的摄取率）无显著差异，恶性和良性病变之间也无差异。然而，在滞留指数（病变中的滞留程度）方面，恶性和良性病变之间存在显著差异（P<0.01），尽管该指数在不同组织学类型的恶性病变组之间无显著差异。这些结果表明，该方法有助于显示直径大于20 mm的恶性肺病变，在未观察到201铊异常聚集时排除病变为恶性的可能性。当病变显示201铊异常聚集时，滞留指数似乎有助于区分恶性和良性病变。
