Senga O, Hikita H, Kinoshita T, Hara K, Miyakawa M, Nishimura H, Tsuchiya S
Department of Surgery, Iida Municipal Hospital, Nagano, Japan.
Surg Today. 1993;23(6):541-5. doi: 10.1007/BF00730632.
Although reports on primary squamous cell carcinoma of the breast have been increasing in number, the morbidity rate of the disease is comparatively low. Its onset in pregnant women, especially, is quite rare. We herein report a case of primary squamous cell carcinoma of the breast in a pregnant woman. A 33-year-old woman was admitted with a lump in the right breast and an abnormal bloody nipple discharge. The breast mass was 5.6 x 5.4 cm in size, and both ultrasonogram and CT scanning showed that it consisted of a cystic tumor for the most part. A large amount of bloody cystic fluid was aspirated by fine-needle aspiration; squamous cell carcinoma of the breast was suspected by a cytological study on the fluid. Twelve days after an induced abortion was performed, a modified radical mastectomy was carried out. Histological findings of the resected specimen demonstrated that the tumor was squamous cell carcinoma which had been well differentiated with partial keratinization and cancer pearls. Noninvasive ductal carcinoma was also observed in a very small region of the specimen, which indicated that the tumor was probably originally adenocarcinoma which later transformed into squamous cell carcinoma.
尽管关于原发性乳腺鳞状细胞癌的报道数量一直在增加，但该疾病的发病率相对较低。尤其是在孕妇中发病极为罕见。我们在此报告一例孕妇原发性乳腺鳞状细胞癌病例。一名33岁女性因右乳肿块及乳头血性溢液异常入院。乳房肿块大小为5.6×5.4厘米，超声检查和CT扫描均显示其大部分由囊性肿瘤组成。通过细针穿刺抽出大量血性囊液；对囊液进行细胞学研究怀疑为乳腺鳞状细胞癌。人工流产12天后，实施了改良根治性乳房切除术。切除标本的组织学检查结果显示，肿瘤为鳞状细胞癌，分化良好，有部分角化和癌珠形成。在标本的一个非常小的区域还观察到非浸润性导管癌，这表明该肿瘤可能最初是腺癌，后来转变为鳞状细胞癌。
