Schirren C G, Eckert F, Kind P
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Hautarzt. 1993 Jul;44(7):457-61.
A 25-year-old patient presented with multiple disseminated asymptomatic bluish nodules, which had been present since childhood. Histological examination revealed vascular cavities surrounded by round to oval eosinophilic cells. Positive immunohistochemical staining with alpha-smooth-muscle antigen (alpha-SMA) and vimentin confirmed the diagnosis of multiple disseminated glomus tumours of the vascular type. Tumour cells were surrounded by a network of type IV collagen. In contrast antibodies against the intermediate filament protein desmin and the endothelial markers BMA 120 and anti-von Willebrand factor revealed no staining of the glomus cells. This was the first immunohistochemical investigation of a glomus tumour of vascular type. Immunohistochemical staining of these glomus cells revealed no difference from other histological types of glomus tumours.
一名25岁患者自童年起就出现多个散在分布的无症状蓝色结节。组织学检查显示血管腔被圆形至椭圆形嗜酸性细胞包围。α-平滑肌抗原（α-SMA）和波形蛋白免疫组化染色阳性，确诊为血管型多发性散在性球瘤。肿瘤细胞被IV型胶原网络包围。相比之下，针对中间丝蛋白结蛋白以及内皮标志物BMA 120和抗血管性血友病因子的抗体未显示球瘤细胞染色。这是首次对血管型球瘤进行免疫组化研究。这些球瘤细胞的免疫组化染色与其他组织学类型的球瘤无差异。
