疣状表皮发育不良中的脂溢性角化病样损害。

Seborrheic keratosis-like lesions in epidermodysplasia verruciformis.

作者信息

Tomasini C, Aloi F, Pippione M

机构信息

Department of Dermatology, University of Turin, Italy.

出版信息

J Cutan Pathol. 1993 Jun;20(3):237-41. doi: 10.1111/j.1600-0560.1993.tb00649.x.

DOI:10.1111/j.1600-0560.1993.tb00649.x

PMID:8396161

Abstract

A light microscopic study of 6 verrucous lesions with clinical features of seborrheic keratoses (SK) occurring on sun-exposed skin of 4 patients with epidermodysplasia verruciformis (EV) was performed. We observed the typical histological findings of SK in all cases. In addition, koilocytotic effects suggestive of EV were observed in the upper prickle layer and stratum granulosum. In 2 lesions, we also noted bowenoid changes suggesting possible early malignant transformation. Immunohistochemical study confirmed the presence of HPV in these lesions.

摘要

对4例疣状表皮发育不良（EV）患者暴露于阳光下皮肤出现的6个具有脂溢性角化病（SK）临床特征的疣状病变进行了光镜研究。我们在所有病例中均观察到SK的典型组织学表现。此外，在棘层上部和颗粒层观察到提示EV的凹空细胞效应。在2个病变中，我们还注意到鲍温样改变，提示可能早期发生恶性转化。免疫组化研究证实这些病变中存在人乳头瘤病毒（HPV）。