[Neurobiological determinants of schizophrenic diseases. Concept, strategy and methods of a research program].

Biological research in schizophrenia aims at clarifying the etiopathogenesis of schizophrenic psychoses and developing causal therapies. Besides the necessary coordination of available resources, the scientific success of such a research program depends mainly on adequate concepts, research strategies, and methods of assessment. The present paper discusses some of these conceptual research aspects.