[促肾上腺皮质激素（ACTH）测定各种方法的临床价值]

[Clinical value of the various methods of ACTH determination].

作者信息

Ramschak-Schwarzer S, Lipp R, Passath A, Warnkross H, Stiegler-Heinz C, Dobnig H, Wascher T, Leb G

机构信息

Abteilung Endokrinologie/Nuklearmedizin, Medizinischen Universitätsklinik Graz.

出版信息

Acta Med Austriaca. 1993;20(3):81-4.

PMID:8396307

Abstract

We determined 293 plasma-ACTH levels out of 49 patients. In 12 patients with various pituitary diseases 168 samples were collected during a standardized pituitary stimulation test. For this purpose we used the following kits: the DYNOtest ACTH and LUMItest ACTH and Allegro HS-ACTH test. Additionally, morning ACTH levels were analyzed from 49 patients using Allegro HS ACTH test and DYNOtest ACTH. Regarding ACTH concentrations during pituitary stimulation the clinical usefulness of the 3 named tests were comparable. Pair differences of morning ACTH levels were not statistically significant. In a setting of a wide range of ACTH levels all 3 trials proved appropriate for making a diagnosis. Practicability of all 3 tests was similar. For all 3 methods incubation can be done overnight which saves time. Reagents can be reused when frozen immediately after reconstitution.

摘要

我们测定了49例患者中的293份血浆促肾上腺皮质激素（ACTH）水平。在12例患有各种垂体疾病的患者中，在标准化垂体刺激试验期间收集了168份样本。为此，我们使用了以下试剂盒：DYNOtest ACTH、LUMItest ACTH和Allegro HS - ACTH检测试剂盒。此外，使用Allegro HS ACTH检测试剂盒和DYNOtest ACTH分析了49例患者的清晨ACTH水平。关于垂体刺激期间的ACTH浓度，上述3种检测方法的临床实用性相当。清晨ACTH水平的配对差异无统计学意义。在ACTH水平范围广泛的情况下，所有3项试验都证明适用于做出诊断。所有3种检测方法的实用性相似。对于所有3种方法，孵育都可以过夜进行，这节省了时间。试剂在复溶后立即冷冻时可重复使用。