Corbin J D, Woodall C C, Colbran J L, McAllister L M, Sekhar K R, Francis S H
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Agents Actions Suppl. 1993;43:27-33. doi: 10.1007/978-3-0348-7324-6_3.
The main protein kinase that phosphorylates cyclic GMP-binding cyclic GMP-specific phosphodiesterase (cG-BPDE) in crude extracts of bovine lung is cyclic GMP-dependent protein kinase. This can be shown by the use of either exogenous or endogenous cG-BPDE as substrate for endogenous cyclic GMP-dependent protein kinase. The characteristics of this phosphorylation suggest a physiological significance.
在牛肺粗提物中，使环鸟苷酸结合型环鸟苷酸特异性磷酸二酯酶（cG - BPDE）磷酸化的主要蛋白激酶是环鸟苷酸依赖性蛋白激酶。使用外源性或内源性cG - BPDE作为内源性环鸟苷酸依赖性蛋白激酶的底物均可证明这一点。这种磷酸化作用的特性表明其具有生理意义。
