Kage M, Kosai K, Kojiro M, Nakamura Y, Fukuda S
First Department of Pathology, Kurume University School of Medicine, Japan.
Arch Pathol Lab Med. 1993 Sep;117(9):942-4.
We report a neonatal case of hepatic cytomegalovirus (CMV) infection associated with paucity of interlobular bile ducts. The premature infant developed severe jaundice, and died of disseminated CMV infection. The diagnosis of CMV infection was based on detection of pathognomonic inclusions in the liver and on a high titer of CMV antibody in the serum. The hepatic histologic findings in this infant included severe cholestasis, complete absence of interlobular bile ducts in the majority of the portal tracts, and CMV inclusions in the duct epithelium. Interestingly, the CMV inclusions were localized in the bile duct, but not in the parenchyma. We postulate that the paucity of interlobular bile ducts may have been a sequela of CMV infection of the liver arising from destruction of the bile ducts, leading to severe cholestasis.
我们报告了一例新生儿肝巨细胞病毒（CMV）感染伴小叶间胆管缺乏的病例。该早产儿出现严重黄疸，死于播散性CMV感染。CMV感染的诊断基于肝脏中特征性包涵体的检测以及血清中高滴度的CMV抗体。该婴儿的肝脏组织学表现包括严重胆汁淤积、大多数门管区小叶间胆管完全缺如以及胆管上皮中的CMV包涵体。有趣的是，CMV包涵体定位于胆管，而非实质。我们推测小叶间胆管缺乏可能是肝脏CMV感染导致胆管破坏后的后遗症，进而引起严重胆汁淤积。
