Molander U
Continence Clinic, Vasa Hospital, Gothenburg, Sweden.
Acta Obstet Gynecol Scand Suppl. 1993;158:1-22. doi: 10.3109/00016349309156515.
The aims of this study were to investigate the prevalence of urinary incontinence (UI), urinary tract infections (UTI) and related urogenital symptoms (UGS) in a representative sample of elderly women (Papers I & II), and to investigate factors (Papers II & III) influencing the prevalence of UI in these women. The effects of treatment with oral estriol and placebo on the vaginal bacterial flora, vaginal cytology and urogenital symptoms in elderly women suffering from the urogenital estrogen deficiency syndrome were compared (Paper IV). A health care programme, based on an algorithm model, for the investigation and treatment of elderly women suffering from UI and related UGS, was designed and applied to a large group of elderly women (Paper V). The prevalence of UI increased in a linear fashion from 12% in the 1940 birth cohort to 25% in the 1900 birth cohort (Papers I & II). There was similar increase in the prevalence of UTI from 14% in the 1920 birth cohort to 23% in the 1900 birth cohort. In contrast, the reported prevalence of UGS such as vaginal discomfort, discharge and pruritus did not increase with age. The prevalence of UI increased with increasing parity and after hysterectomy, but was unaffected by the duration of previous oral contraceptive usage. There was no evidence to suggest that the prevalence of UI increased at the time of the last menstrual period. Neurological illnesses were an uncommon cause of UI in women < or = to 75 years of age (Paper III). Oral estriol (3 mg/day for 4 weeks followed by 2 mg/day for a further 6 weeks) had a positive influence on vaginal pH, cytology and the vaginal bacteria flora, and on UGS in elderly women suffering from the urogenital estrogen deficiency syndrome (Paper IV). Using objective techniques of evaluation (Paper V) it was possible to demonstrate successful treatment of elderly women with urge and mixed incontinence using a simple health care programme. There was however no evidence of improvement in women suffering from stress incontinence when using the same treatment regime. Women with all types of incontinence, treated according to this algorithm model, displayed an improvement in vaginal pH, vaginal cytology and the vaginal bacterial flora.
本研究的目的是调查老年女性代表性样本中尿失禁(UI)、尿路感染(UTI)及相关泌尿生殖系统症状(UGS)的患病率(论文一和论文二),并调查影响这些女性尿失禁患病率的因素(论文二和论文三)。比较了口服雌三醇和安慰剂治疗对患有泌尿生殖系统雌激素缺乏综合征的老年女性阴道细菌菌群、阴道细胞学及泌尿生殖系统症状的影响(论文四)。设计了一个基于算法模型的医疗保健项目,用于调查和治疗患有尿失禁及相关泌尿生殖系统症状的老年女性,并将其应用于一大组老年女性(论文五)。尿失禁的患病率从1940年出生队列中的12%呈线性上升至1900年出生队列中的25%(论文一和论文二)。尿路感染的患病率也有类似上升,从1920年出生队列中的14%升至1900年出生队列中的23%。相比之下,所报告的诸如阴道不适、分泌物及瘙痒等泌尿生殖系统症状的患病率并未随年龄增长而增加。尿失禁的患病率随产次增加及子宫切除术后上升,但不受既往口服避孕药使用时长的影响。没有证据表明在末次月经时尿失禁患病率会增加。神经疾病在75岁及以下女性中并非尿失禁的常见病因(论文三)。口服雌三醇(每日3毫克,持续4周,之后每日2毫克再持续6周)对患有泌尿生殖系统雌激素缺乏综合征的老年女性的阴道pH值、细胞学、阴道细菌菌群及泌尿生殖系统症状有积极影响(论文四)。使用客观评估技术(论文五)能够证明,采用一个简单的医疗保健项目可成功治疗患有急迫性和混合性尿失禁的老年女性。然而,使用相同治疗方案时,没有证据表明压力性尿失禁女性的病情有所改善。按照此算法模型接受治疗的各类尿失禁女性,其阴道pH值、阴道细胞学及阴道细菌菌群均有改善。