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Endothelin receptors in rat cerebellum: activation of phosphoinositide hydrolysis is transduced by multiple G-proteins.

作者信息

Sokolovsky M

机构信息

Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel.

出版信息

Cell Signal. 1993 Jul;5(4):473-83. doi: 10.1016/0898-6568(93)90087-3.

DOI:10.1016/0898-6568(93)90087-3
PMID:8396963
Abstract

Induction of phosphoinositide hydrolysis in rat cerebellar slices by endothelins (ET-1 and ET-3) and sarafotoxins (SRTX-b and SRTX-c) was demonstrated by measurement of labelled inositol phosphate generation. Pertussis toxin (PT) enhanced the induction of phosphoinositide hydrolysis by all four peptides. The process seems to be mediated by at least two heterotrimeric G-proteins, the one sensitive and the other insensitive to PT. Measurement of the GTPase activity induced in this preparation indicated that phosphoinositide hydrolysis is stimulated via a functional coupling between the endothelin receptor of the ETB-R subtype and a PT-insensitive G-protein family, i.e. Gq/11. The involvement of PT-sensitive G-proteins, i.e. Gi-like and/or Go-like proteins, in the stimulation of phosphoinositide hydrolysis by ETs and SRTXs is discussed.

摘要

相似文献

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引用本文的文献

1
Functional coupling of G proteins to endothelin receptors is ligand and receptor subtype specific.G蛋白与内皮素受体的功能偶联具有配体和受体亚型特异性。
Cell Mol Neurobiol. 2000 Jun;20(3):305-17. doi: 10.1023/a:1007010125316.
2
Immortalized schwann cells express endothelin receptors coupled to adenylyl cyclase and phospholipase C.永生化雪旺细胞表达与腺苷酸环化酶和磷脂酶C偶联的内皮素受体。
Neurochem Res. 1997 Apr;22(4):409-18. doi: 10.1023/a:1027351525446.
3
Endothelin receptor heterogeneity, G-proteins, and signaling via cAMP and cGMP cascades.
内皮素受体异质性、G蛋白以及通过环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）级联反应的信号传导。
Cell Mol Neurobiol. 1995 Oct;15(5):561-71. doi: 10.1007/BF02071317.