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亨廷顿病及对照病例的组织化学研究。

A histochemical study in Huntington's disease and control cases.

作者信息

den Hartog Jager W A

出版信息

Histochemistry. 1978 Dec 13;58(4):273-80. doi: 10.1007/BF00495383.

DOI:10.1007/BF00495383
PMID:83973
Abstract
  1. Extracellular deposits of cerebrosides and free fatty acids were found in the formaldehyde fixed frozen sections of the frontal lobe in 8 cases of Huntington's disease, in one case of the infantile form of Gaucher's disease, 2 cases of Krabbe's globoid cell leucodystrophy, 2 cases of metachromatic leucodystrophy, one case with multiple sclerosis, 2 cases with cerebral contusion and one case with bacterial meningitis. 2. The cerebroside deposits were present in the white matter as well as in the grey matter. 3. The significance of these findings in relation to their etiology is discussed.
摘要
  1. 在8例亨廷顿病、1例婴儿型戈谢病、2例克拉伯球状细胞脑白质营养不良、2例异染性脑白质营养不良、1例多发性硬化、2例脑挫伤和1例细菌性脑膜炎患者额叶的甲醛固定冰冻切片中发现了脑苷脂和游离脂肪酸的细胞外沉积物。2. 脑苷脂沉积物存在于白质和灰质中。3. 讨论了这些发现与其病因学相关的意义。

相似文献

1
A histochemical study in Huntington's disease and control cases.亨廷顿病及对照病例的组织化学研究。
Histochemistry. 1978 Dec 13;58(4):273-80. doi: 10.1007/BF00495383.
2
Brain sphingoglycolipids in Krabbe's globoid cell leucodystrophy.克拉伯病球状细胞脑白质营养不良中的脑鞘糖脂
J Neurochem. 1971 Mar;18(3):503-11. doi: 10.1111/j.1471-4159.1971.tb11978.x.
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Biochemical studies in Huntington's chorea. VII. The lipid composition of the cerebral white and gray matter.亨廷顿舞蹈病的生化研究。VII. 脑白质和灰质的脂质成分。
Neurology. 1968 Apr;18(4):408-12. doi: 10.1212/wnl.18.4.408.
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Renal cerebroside in globoid cell leukodystrophy (Krabbe's disease).球形细胞脑白质营养不良症(克拉伯病)中的肾脑苷脂。
Lipids. 1971 Jun;6(6):433-6. doi: 10.1007/BF02531383.
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[Lipid and fatty acid composition of the frozen brain specimen in sudanophilic leucodystrophy].[苏丹ophilic白质营养不良症中冷冻脑标本的脂质和脂肪酸组成]
No To Shinkei. 1972 Mar;14(3):281-9.
6
Chemical pathology of Krabbe's disease. II. Fatty acid composition of cerebrosides, sulfatides and sphingomyelins in brain.
Acta Paediatr Scand. 1974 Jul;63(4):501-6. doi: 10.1111/j.1651-2227.1974.tb04839.x.
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Late-onset globoid cell leucodystrophy (Krabbe's disease). Clinical and genetic delineation of two forms and their relation to the early-infantile form.迟发性球状细胞脑白质营养不良(克拉伯病)。两种类型的临床和遗传学描述及其与早发性婴儿型的关系。
Neuropediatrics. 1985 Aug;16(3):137-42. doi: 10.1055/s-2008-1052558.
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[Clinical, anatomical-pathological, ultrastructural, biochemical and enzymatic studies in 2 cases of Krabbe's disease].[2例克拉伯病的临床、解剖病理学、超微结构、生化及酶学研究]
Monatsschr Kinderheilkd (1902). 1970 Jun;118(6):259-61.
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Pathological and biochemical study of metachromatic leucodystrophy.异染性脑白质营养不良的病理与生化研究
Med J Osaka Univ. 1968 Mar;18(4):361-71.
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The fatty acid composition of sphingomyelin from adult human cerebral white matter and changes in childhood, senium and unspecific brain damage.
J Neurol. 1977 Aug 18;216(1):57-65. doi: 10.1007/BF00312817.

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Antioxid Redox Signal. 2024 Dec;41(16-18):1073-1099. doi: 10.1089/ars.2024.0676. Epub 2024 Nov 22.
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The long and the short of Huntington's disease: how the sphingolipid profile is shifted in the caudate of advanced clinical cases.亨廷顿舞蹈症的来龙去脉:晚期临床病例尾状核中鞘脂谱如何发生变化。
Brain Commun. 2021 Dec 23;4(1):fcab303. doi: 10.1093/braincomms/fcab303. eCollection 2022.
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Alteration of lipid-phase behavior in multiple sclerosis myelin revealed by wide-angle x-ray diffraction.

本文引用的文献

1
Studies in lipid histochemistry. IX. The specifity of the Holczinger's reaction for fatty acids.脂质组织化学研究。IX. 霍尔钦格反应对脂肪酸的特异性。
Histochemie. 1972;32(4):301-5. doi: 10.1007/BF00305764.
广角X射线衍射揭示多发性硬化症髓鞘中脂质相行为的改变。
Proc Natl Acad Sci U S A. 1984 Mar;81(6):1871-4. doi: 10.1073/pnas.81.6.1871.