树突状细胞是微生物超抗原的高效抗原呈递细胞。
Dendritic cells are potent antigen-presenting cells for microbial superantigen.
作者信息
Iqball S, Bhatt R, Bedford P, Borriello P, Knight S
机构信息
Antigen Presentation Research Group, Clinical Research Centre, Harrow, Middlesex.
出版信息
Adv Exp Med Biol. 1993;329:41-6. doi: 10.1007/978-1-4615-2930-9_7.
PMID:8397474
Abstract
Dendritic cells (DC) were found to be more efficient than macrophages (MO) in activating T cell responses to Staphylococcal enterotoxin B (SEB) using the hanging drop techniques and DC as antigen presenting cells (APC). When superantigen was presented via DC, the activation of T cells was not dependent on antigen processing and MHC class II molecules IA and IE were involved.
摘要
利用悬滴技术并将树突状细胞（DC）作为抗原呈递细胞（APC），研究发现树突状细胞在激活针对葡萄球菌肠毒素B（SEB）的T细胞反应方面比巨噬细胞（MO）更有效。当通过树突状细胞呈递超抗原时，T细胞的激活不依赖于抗原加工，且涉及MHC II类分子IA和IE。
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