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表皮朗格汉斯细胞对皮肤利什曼病的免疫调节至关重要。

Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis.

作者信息

Moll H

机构信息

Institute of Clinical Microbiology, University of Erlangen-Nürnberg, Germany.

出版信息

Immunol Today. 1993 Aug;14(8):383-7. doi: 10.1016/0167-5699(93)90138-B.

DOI:10.1016/0167-5699(93)90138-B
PMID:8397776
Abstract

In leishmaniasis, macrophages are known to play a central role as modulators of the specific immune activity. In this article, Heidrun Moll presents evidence for the critical involvement of another component of the skin immune system, the epidermal Langerhans cell. She proposes that Langerhans cells take up parasites in the skin and transport them to the draining lymph node for presentation to T cells and initiation of the specific immune response.

摘要

在利什曼病中，巨噬细胞作为特异性免疫活动的调节因子发挥着核心作用。在本文中，海德伦·莫尔提供了证据，证明皮肤免疫系统的另一个组成部分——表皮朗格汉斯细胞也至关重要。她提出，朗格汉斯细胞在皮肤中摄取寄生虫，并将其转运至引流淋巴结，以呈递给T细胞并启动特异性免疫反应。

相似文献

1
Epidermal Langerhans cells are critical for immunoregulation of cutaneous leishmaniasis.表皮朗格汉斯细胞对皮肤利什曼病的免疫调节至关重要。
Immunol Today. 1993 Aug;14(8):383-7. doi: 10.1016/0167-5699(93)90138-B.
2
Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells.朗格汉斯细胞将大型利什曼原虫从受感染的皮肤转运至引流淋巴结，以便呈递给抗原特异性T细胞。
Eur J Immunol. 1993 Jul;23(7):1595-601. doi: 10.1002/eji.1830230730.
3
Murine epidermal Langerhans cells are potent stimulators of an antigen-specific T cell response to Leishmania major, the cause of cutaneous leishmaniasis.小鼠表皮朗格汉斯细胞是针对皮肤利什曼病的病原体硕大利什曼原虫的抗原特异性T细胞反应的有效刺激物。
Eur J Immunol. 1992 Jun;22(6):1341-7. doi: 10.1002/eji.1830220603.
4
CD8 alpha- and Langerin-negative dendritic cells, but not Langerhans cells, act as principal antigen-presenting cells in leishmaniasis.CD8α和朗格汉斯细胞素阴性的树突状细胞而非朗格汉斯细胞，在利什曼病中作为主要的抗原呈递细胞发挥作用。
Eur J Immunol. 2004 Jun;34(6):1542-50. doi: 10.1002/eji.200324586.
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The role of chemokines and accessory cells in the immunoregulation of cutaneous leishmaniasis.趋化因子和辅助细胞在皮肤利什曼病免疫调节中的作用。
Behring Inst Mitt. 1997 Mar(99):73-8.
6
Experimental cutaneous leishmaniasis: Langerhans cells internalize Leishmania major and induce an antigen-specific T-cell response.实验性皮肤利什曼病：朗格汉斯细胞内化硕大利什曼原虫并诱导抗原特异性T细胞反应。
Adv Exp Med Biol. 1993;329:587-92. doi: 10.1007/978-1-4615-2930-9_98.
7
Dendritic cells in Leishmania major-immune mice harbor persistent parasites and mediate an antigen-specific T cell immune response.感染硕大利什曼原虫的免疫小鼠体内的树突状细胞含有持续性寄生虫，并介导抗原特异性T细胞免疫反应。
Eur J Immunol. 1995 Mar;25(3):693-9. doi: 10.1002/eji.1830250310.
8
Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes.接触致敏小鼠引流淋巴结中携带抗原的树突状细胞：与淋巴细胞的簇形成。
Immunology. 1991 Sep;74(1):139-45.
9
Dendritic cells seclude Leishmania parasites that persist in cured mice--a role in the maintenance of T-cell memory?树突状细胞隔离持续存在于治愈小鼠体内的利什曼原虫寄生虫——这在T细胞记忆维持中起作用吗？
Adv Exp Med Biol. 1995;378:507-9. doi: 10.1007/978-1-4615-1971-3_114.
10
Antigen-presenting cells in human cutaneous leishmaniasis due to Leishmania major.由硕大利什曼原虫引起的人类皮肤利什曼病中的抗原呈递细胞
Clin Exp Immunol. 1995 Mar;99(3):445-53. doi: 10.1111/j.1365-2249.1995.tb05571.x.

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Med Microbiol Immunol. 2007 Mar;196(1):51-9. doi: 10.1007/s00430-006-0023-0. Epub 2006 Jun 20.
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