Smotherman W P, Robinson S R
Department of Psychology, Binghamton University, New York 13902-6000.
Behav Neurosci. 1993 Aug;107(4):611-7. doi: 10.1037//0735-7044.107.4.611.
On Day 21 of gestation, rat fetuses respond to chemosensory stimuli by expressing stereotypic facial wiping behavior. A series of 4 experiments was conducted to investigate (a) the influence of morphine on fetal responsiveness to a single chemosensory infusion, (b) the effect of naloxone blockade of endogenous opioid activity on diminished fetal responsiveness over a series of chemosensory infusions, (c) the effect of endogenous opioids on the recovery of fetal responsiveness to infusion after various dishabituation procedures, and (d) the influence of selective mu and kappa opioid receptor antagonists on fetal habituation. These experiments confirm that fetuses habituate after a brief series of chemosensory infusions and that dishabituation promoted by presentation of a novel stimulus is facilitated by pharmacological blockade of kappa opioid receptors. Endogenous activity in the kappa opioid system may be functional in modulating the sensory environment around the time of birth.
在妊娠第21天，大鼠胎儿通过表现出刻板的面部擦拭行为对化学感觉刺激做出反应。进行了一系列4个实验，以研究（a）吗啡对胎儿对单次化学感觉输注反应性的影响，（b）纳洛酮阻断内源性阿片样物质活性对一系列化学感觉输注过程中胎儿反应性降低的影响，（c）内源性阿片样物质对各种去习惯化程序后胎儿对输注反应性恢复的影响，以及（d）选择性μ和κ阿片受体拮抗剂对胎儿习惯化的影响。这些实验证实，胎儿在经过一系列短暂的化学感觉输注后会产生习惯化，并且通过κ阿片受体的药理学阻断促进了由新刺激呈现所促进的去习惯化。κ阿片系统中的内源性活性可能在出生时调节感觉环境方面发挥作用。
