以克山病病区谷物为食的大鼠对维生素E的需求量

Vitamin E requirement of rats fed on a diet containing grains from the endemic region of Keshan disease.

作者信息

Yang Q, Wang F

机构信息

Pathophysiology Department of Beijing Medical University, China.

出版信息

Biomed Environ Sci. 1993 Jun;6(2):207-10.

PMID:8397903

Abstract

Keshan disease (KD) is an endemic cardiomyopathy occurring in China. Combined selenium and vitamin E (VE) deficiency might be involved in the development of KD. It was shown in this paper that addition of 20 and 100 mg/kg DL-alpha-tocopherol tended to decrease malondialdehyde (MDA) content of myocardium in the rats receiving the low selenium (0.013 ppm) grains from the endemic region of KD, but not to a statistically significant extent. And addition of 200 mg/kg DL-alpha-tocopherol significantly decreased the myocardial MDA content, which suggested that VE requirement of the rats receiving KD endemic grains was 200 mg/kg DL-alpha-tocopherol. However, the MDA content in the myocardium of rats receiving KD grains added with 100 mg/kg DL-alpha-tocopherol was significantly decreased when selenium (0.1 ppm) was supplemented, which suggested that VE requirement of these rats was decreased to 100 mg/kg DL-alpha-tocopherol in the presence of selenium. The ability of VE in counteracting free radicals in myocardium of rats appeared greater than that of selenium.

摘要

克山病（KD）是一种在中国发生的地方性心肌病。硒和维生素E（VE）联合缺乏可能与克山病的发病有关。本文研究表明，在来自克山病病区、摄入低硒（0.013 ppm）谷物的大鼠中，添加20和100 mg/kg DL-α-生育酚倾向于降低心肌丙二醛（MDA）含量，但未达到统计学显著水平。添加200 mg/kg DL-α-生育酚可显著降低心肌MDA含量，这表明摄入克山病病区谷物的大鼠对VE的需求量为200 mg/kg DL-α-生育酚。然而，当补充硒（0.1 ppm）时，摄入添加100 mg/kg DL-α-生育酚的克山病病区谷物的大鼠心肌MDA含量显著降低，这表明在有硒存在的情况下，这些大鼠对VE的需求量降至100 mg/kg DL-α-生育酚。VE对抗大鼠心肌自由基的能力似乎大于硒。