Petrovich Z, Wollman J, Acquarelli M, Barton R
J Surg Oncol. 1977;9(1):21-8. doi: 10.1002/jso.2930090105.
A case of malignant teratoma of the nasal cavity in an adult is presented. Histologically, the tumor consisted of mesenchymal malignant structures in addition to entodermal and ectodermal malignant elements. Whereas surgical treatment of the primary tumor has been generally considered preferred, this patient was given a full course of radiation therapy alone to the primary lesion. There is no clinical evidence of tumor 5 years following diagnosis. Three years following treatment of the primary tumor, neck lymph node metastasis appeared contralaterally. Management of this problem was with radical neck dissection followed by postoperative radiotherapy. Function of the eyes, nose, and paranasal sinuses remains normal. A review of the literature suggests that radiotherapy is of little value in the management of malignant teratomas. This case demonstrates an opposite point of view.
本文报告一例成人生鼻腔恶性畸胎瘤。组织学上，肿瘤除了内胚层和外胚层恶性成分外，还包含间充质恶性结构。虽然原发性肿瘤的手术治疗通常被认为是首选，但该患者仅对原发性病变进行了全程放射治疗。诊断后5年无肿瘤的临床证据。原发性肿瘤治疗3年后，对侧颈部出现淋巴结转移。对此问题的处理是行根治性颈清扫术，术后进行放射治疗。眼、鼻和鼻窦功能仍正常。文献回顾表明，放射治疗在恶性畸胎瘤的治疗中价值不大。本病例则显示了相反的观点。
