Strong L C, Matsunaga H
J Surg Oncol. 1977;9(1):99-103. doi: 10.1002/jso.2930090115.
Three hundred and seventy-one mice of the C3H/St inbreds bearing spontaneous tumors of mammary gland origin have been used in this experiment. All mice studied were lineal descendents of a tumor-bearing mouse which had been injected with a liver extract. In this descent there appears to be a transmissible entity presumably induced by the injection of the liver extract. Following 15 generations of inbreeding after the appearance of a transmissible entity, a second sudden reversal of effect on cancer growth in mice has been indicated. This change has progressively altered the growth of cancer from a very low effect to a maximal effect, i.e., to a complete regression of a high percentage of the tumor. The maximal effect of the transmissible entity is the complete suppression of the growth of cancer during, at least, through the 25th period of observation, thus producing negative values of tumor growth. All these effects of the growth and fate of spontaneous tumors of mammary gland origin in mice have been obtained in a single lineal descent of C3H/St inbreds without resorting to any outcross.
本实验使用了371只C3H/St近交系自发乳腺肿瘤小鼠。所有研究的小鼠都是一只注射了肝提取物的荷瘤小鼠的直系后代。在这个谱系中，似乎存在一种可能由注射肝提取物诱导的可传播实体。在出现可传播实体后经过15代近亲繁殖，已表明对小鼠癌症生长的影响出现了第二次突然逆转。这种变化逐渐改变了癌症的生长，从非常低的影响变为最大影响，即高比例的肿瘤完全消退。可传播实体的最大影响是至少在第25个观察期内完全抑制癌症生长，从而产生肿瘤生长的负值。小鼠乳腺起源的自发肿瘤的生长和命运的所有这些影响都是在C3H/St近交系的单一谱系中获得的，而无需进行任何杂交。
