Weiner B
Crit Care Nurs Clin North Am. 1993 Jun;5(2):355-66.
Thrombolytic therapy, when instituted early in optimum dosage, has had an important role in improving the survival of critically ill patients. Thrombolysis is but one component of the processes associated with hemostasis, the mechanism by which humans are protected from death by hemorrhage following injury to a blood vessel. The natural process of thrombolysis is mediated by plasmin, the primary protein responsible for clot lysis. Recent studies have established the efficacy of the intravenous administration of thrombolytic agents in decreasing mortality and improving patient outcome.
溶栓治疗若能在早期以最佳剂量实施，对于提高重症患者的生存率具有重要作用。溶栓只是与止血相关过程的一个组成部分，止血是人体在血管受伤后防止因出血而死亡的机制。溶栓的自然过程由纤溶酶介导，纤溶酶是负责溶解血栓的主要蛋白质。最近的研究证实了静脉注射溶栓药物在降低死亡率和改善患者预后方面的疗效。
