Tait D M, Eeles R A, Carter R, Ashley S, Ormerod M G
Paediatric Unit, Royal Marsden Hospital, Sutton, Surrey, U.K.
Eur J Cancer. 1993;29A(10):1383-7. doi: 10.1016/0959-8049(93)90006-2.
Paraffin sections from 32 patients with primary medulloblastoma were analysed by flow cytometry for DNA ploidy and proliferative index to assess the value of these measurements in determining prognosis. Twenty-seven samples were informative. Of these 27 patients, 8 had had a total resection. The tumors were diploid in 13 patients and aneuploid in 14. Neither ploidy nor S-phase fraction were prognostic factors for survival, even when considered in conjunction with the type of surgery performed. This is in contrast to other published data, emphasising the need for large multicentre studies of biological prognostic factors in this rare tumour.
对32例原发性髓母细胞瘤患者的石蜡切片进行流式细胞术分析，以检测DNA倍性和增殖指数，从而评估这些测量指标在判断预后方面的价值。27个样本提供了有效信息。在这27例患者中，8例进行了全切除。13例患者的肿瘤为二倍体，14例为非整倍体。无论是倍性还是S期分数都不是生存的预后因素，即使结合所施行的手术类型考虑也是如此。这与其他已发表的数据形成对比，强调了对这种罕见肿瘤的生物学预后因素进行大型多中心研究的必要性。
