McClenathan J H, Guyton R A, Breyer R H, Newman G E, Michaelis L L
J Thorac Cardiovasc Surg. 1977 Mar;73(3):431-5.
The effects of isoproterenol and dopamine on regional myocardial blood flow were studied in 10 open-chest dogs after acute stenosis of the proximal circumflex coronary artery. Blood flow was determined by the radioactive microsphere technique. Isoproterenol led to a homogenous increase in blood flow in the normal myocardium. In the myocardium with compromised coronary blood flow, isoproterenol led to a relative subendocardial ischemia. This occurred despite increased aortic flow and peak left ventricular dp/dt. Dopamine also increased aortic flow and peak left ventricular dp/dt, but it did not cause regional myocardial ischemia. The findings suggest that dopamine is the preferable inotropic agent in managing low cardiac output in patients with significant coronary artery disease.
在10只开胸犬急性左旋冠状动脉近端狭窄后，研究了异丙肾上腺素和多巴胺对局部心肌血流的影响。采用放射性微球技术测定血流。异丙肾上腺素使正常心肌的血流均匀增加。在冠状动脉血流受损的心肌中，异丙肾上腺素导致相对的心内膜下缺血。尽管主动脉血流量和左心室dp/dt峰值增加，但仍会出现这种情况。多巴胺也增加了主动脉血流量和左心室dp/dt峰值，但它不会引起局部心肌缺血。这些发现表明，在治疗患有严重冠状动脉疾病且心输出量低的患者时，多巴胺是更可取的正性肌力药物。
