[DNA作为结直肠癌的预后因素。对34例患者的回顾性分析]
[DNA as a prognostic factor in colorectal cancer. A retrospective analysis of 34 patients].
作者信息
Bianchi A, Mallofre C, Serrano A, Suñol J, Barja J, Ubach M
机构信息
Servicio Cirugía General, Consorci Sanitari de Mataró, Hospital Sant Jaume i Sta. Magdalena.
出版信息
Rev Esp Enferm Dig. 1993 Aug;84(2):100-4.
OBJECTIVE
We study the tumoral DNA as a prognostic factor in patients operated for colo-rectal cancer.
DESIGN
Retrospective. We analyze by flow cytometry the DNA content of tumoral tissue: Ploidy, DNA Index, Proliferative Index, S Phase.
PATIENTS
34 operated patients, for colo-rectal cancer, with a minimum 3 years of follow-up.
RESULTS
Ploidy doesn't show any relation with other prognostic factors. Only Dukes C aneuploid patients had more positive nodes than diploid. Ploidy was not related to better evolution or survival. Neither DNA Index, Proliferative Index and S Phase were related to the evolution of the disease.
CONCLUSIONS
The DNA study by flow cytometry has no better prognostic value then other classical factors.
目的
我们研究肿瘤DNA作为接受结直肠癌手术患者的预后因素。
设计
回顾性研究。我们通过流式细胞术分析肿瘤组织的DNA含量：倍体、DNA指数、增殖指数、S期。
患者
34例接受结直肠癌手术的患者，至少随访3年。
结果
倍体与其他预后因素无任何关联。仅杜克C期非整倍体患者的阳性淋巴结比二倍体患者更多。倍体与更好的病情进展或生存无关。DNA指数、增殖指数和S期均与疾病进展无关。
结论
流式细胞术进行的DNA研究没有比其他经典因素更好的预后价值。
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