Bakker A, De Bie M, Bernaert I, Ravingerova T, Ziegelhöffer A, Van Belle H, Jacob W
University of Antwerp (UIA), Dept. of Medicine, Belgium.
Eur J Morphol. 1993 Mar-Jun;31(1-2):46-50.
In our previous study, mitochondrial creatine kinase (Mi-CK) activity is localised cytochemically in heart tissue. The activity was found to be exclusively localised in mitochondrial contact sites and the surface density of Mi-CK was increased upon myocardial stimulation (Biermans et al., 1989). As calcium is involved as an intracellular messenger of stimulation, we compared hearts noradrenaline-stimulated in vivo with isolated hearts perfused with buffers containing different calcium concentrations on the surface density Mi-CK.
在我们之前的研究中，线粒体肌酸激酶（Mi-CK）活性通过细胞化学方法定位在心脏组织中。发现该活性仅定位于线粒体接触部位，并且在心肌刺激后Mi-CK的表面密度增加（比尔曼斯等人，1989年）。由于钙作为刺激的细胞内信使参与其中，我们比较了体内去甲肾上腺素刺激的心脏与用含有不同钙浓度的缓冲液灌注的离体心脏中Mi-CK的表面密度。
