接受胺碘酮治疗的患者肌酐升高与血清胺碘酮浓度相关。
Creatinine elevation in patients receiving amiodarone correlates with serum amiodarone concentration.
作者信息
Pollak P T, Sharma A D, Carruthers S G
机构信息
Department of Medicine, Dalhousie University, Victoria General Hospital, Halifax, Nova Scotia, Canada.
出版信息
Br J Clin Pharmacol. 1993 Aug;36(2):125-7. doi: 10.1111/j.1365-2125.1993.tb04207.x.
Abstract
Serum creatinine and drug concentrations were measured at 0, 1, 2, 3, 6, 9 and 12 months in 30 consecutive patients started on amiodarone. In 28 of these patients with no obvious cause for altered renal function, mean serum creatinine increased to 11% above baseline (P < 0.005). Rising creatinine concentrations correlated with amiodarone concentrations (y = 93.9 + 8.6x, r = 0.51, P < 0.0001). When assessing elevation of serum creatinine in a patient receiving amiodarone, physicians should be aware that it may be related to this drug.
摘要
对连续30例开始服用胺碘酮的患者在0、1、2、3、6、9和12个月时测定血清肌酐和药物浓度。在其中28例肾功能改变无明显原因的患者中，血清肌酐均值升高至高于基线水平11%（P<0.005）。肌酐浓度升高与胺碘酮浓度相关（y = 93.9 + 8.6x，r = 0.51，P<0.0001）。在评估服用胺碘酮患者的血清肌酐升高情况时，医生应意识到这可能与该药物有关。
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