Hochberg M C, Petri M
Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore 21201.
Curr Opin Rheumatol. 1993 Sep;5(5):575-86. doi: 10.1097/00002281-199305050-00005.
Descriptive and analytic clinical research investigations dealing with systemic lupus erythematosus have focused on disease manifestations involving the heart, kidneys, and central nervous system, the complications of corticosteroid therapy, particularly cardiovascular and peripheral vascular disease, and outcomes of pregnancy. Studies exploring prognostic factors in patients with lupus nephritis as well as risk factors for the development of cardiovascular disease emphasize the importance of control of comorbid conditions, particularly hypertension and hyperlipidemia, in preventing poor outcomes in patients with systemic lupus erythematosus. The effectiveness of parenterally administered pulse cyclophosphamide has been demonstrated in patients with severe central nervous system involvement, and the effectiveness of plasmapheresis in patients with thrombotic thrombocytopenic purpura was reviewed.
关于系统性红斑狼疮的描述性和分析性临床研究主要集中在涉及心脏、肾脏和中枢神经系统的疾病表现、皮质类固醇治疗的并发症，尤其是心血管和外周血管疾病，以及妊娠结局。探索狼疮性肾炎患者预后因素以及心血管疾病发生风险因素的研究强调，控制合并症，尤其是高血压和高脂血症，对于预防系统性红斑狼疮患者出现不良结局至关重要。静脉注射脉冲环磷酰胺在严重中枢神经系统受累患者中的有效性已得到证实，并且对血栓性血小板减少性紫癜患者进行血浆置换的有效性也进行了综述。
