Wendelhag I, Wiklund O, Wikstrand J
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Hospital, University of Gothenburg, Sweden.
Arterioscler Thromb. 1993 Oct;13(10):1404-11. doi: 10.1161/01.atv.13.10.1404.
B-mode ultrasound is increasingly used in clinical research to study the atherosclerotic process in the carotid arteries. The present investigation evaluated the feasibility of measuring intima-media thickness in the common femoral artery and assessed whether such measurement might provide further information on the extent of the atherosclerotic process in patients with familial hypercholesterolemia. A further aim was to study the relationship between the intima-media thickness of the common carotid artery and the occurrence of plaque in the carotid and femoral arteries. The results showed an increased intima-media thickness in the far wall of the common femoral artery in patients with familial hypercholesterolemia compared with the control subjects (P < .01). The results also showed a clear relationship between the thickness of the intima-media complex in the common carotid artery and the prevalence of plaque in the carotid and femoral arteries. This may be interpreted as an indication that an increase in intima-media thickness in the common carotid artery at least partly expresses a generalized atherosclerotic process. The atherosclerotic changes appeared to be more advanced in the femoral artery compared with the carotid artery. In future studies, therefore, valuable information on different stages of atherosclerotic changes may be achieved by combining information from B-mode recordings from both the carotid and femoral arteries.
B 型超声越来越多地用于临床研究，以研究颈动脉的动脉粥样硬化进程。本研究评估了测量股总动脉内膜中层厚度的可行性，并评估这种测量是否能为家族性高胆固醇血症患者的动脉粥样硬化进程程度提供更多信息。另一个目的是研究颈总动脉内膜中层厚度与颈动脉和股动脉斑块发生之间的关系。结果显示，与对照组相比，家族性高胆固醇血症患者股总动脉远壁的内膜中层厚度增加（P <.01）。结果还显示，颈总动脉内膜中层复合体厚度与颈动脉和股动脉斑块患病率之间存在明显关系。这可以解释为颈总动脉内膜中层厚度增加至少部分表明存在全身性动脉粥样硬化进程的一个迹象。与颈动脉相比，股动脉的动脉粥样硬化变化似乎更严重。因此，在未来的研究中，通过结合来自颈动脉和股动脉的 B 型记录信息，可能会获得有关动脉粥样硬化变化不同阶段的有价值信息。
