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慢性肾衰竭患者重组人促红细胞生成素治疗期间血细胞比容对腹膜透析有效性的影响。

Hematocrit influence on peritoneal dialysis effectiveness during recombinant human erythropoietin treatment in patients with chronic renal failure.

作者信息

Ksiazek A, Baranowska-Daca E

机构信息

Nephrology Department, Medical Academy of Lublin, Poland.

出版信息

Perit Dial Int. 1993;13 Suppl 2:S550-2.

PMID:8399662
Abstract

Seven intermittent peritoneal dialysis (IPD) patients were investigated before and after correction of anemia with recombinant human erythropoietin (r-HuEPO). When hematocrit exceeded 30%, the peritoneal equilibration test was performed at 1, 2, 4, 8 hours. Correction of anemia was associated with a mean value increment in creatinine and phosphate clearance in 1- and 2-hour dwells. Differences in clearance of sodium, potassium, and urea in protein loss and glucose absorption before and after r-HuEPO therapy were not statistically significant. Increased creatinine and phosphate clearance during short dwells can be effected in IPD patients.

摘要

对7例间歇性腹膜透析(IPD)患者在使用重组人促红细胞生成素(r-HuEPO)纠正贫血前后进行了研究。当血细胞比容超过30%时,在1、2、4、8小时进行腹膜平衡试验。贫血的纠正与1小时和2小时留腹时肌酐和磷酸盐清除率的平均值增加有关。r-HuEPO治疗前后钠、钾、尿素清除率、蛋白质丢失和葡萄糖吸收的差异无统计学意义。IPD患者在短时间留腹时可实现肌酐和磷酸盐清除率的增加。

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1
Hematocrit influence on peritoneal dialysis effectiveness during recombinant human erythropoietin treatment in patients with chronic renal failure.慢性肾衰竭患者重组人促红细胞生成素治疗期间血细胞比容对腹膜透析有效性的影响。
Perit Dial Int. 1993;13 Suppl 2:S550-2.
2
Renal function during erythropoietin therapy for anemia in predialysis chronic renal failure patients.促红细胞生成素治疗透析前慢性肾衰竭患者贫血期间的肾功能
Am J Nephrol. 1990;10(2):128-36. doi: 10.1159/000168067.
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Peritoneal dialysis efficiency in CAPD patients in treatment with rHuEPO.
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Effectiveness and safety of recombinant human erythropoietin (r-HuEPO) in the treatment of anemia of chronic renal failure in non dialysis patients. European Multicentre Study Group.重组人促红细胞生成素(r-HuEPO)治疗非透析慢性肾衰竭患者贫血的有效性和安全性。欧洲多中心研究组。
Int J Artif Organs. 1994 Apr;17(4):195-202.
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Dialyzer urea and creatinine clearances are not significantly altered in erythropoietin treated maintenance hemodialysis patients.在接受促红细胞生成素治疗的维持性血液透析患者中,透析器对尿素和肌酐的清除率没有显著改变。
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