Synthesis and structure-activity relationships of 1-aminophthalazinium bromides as GABAA receptor ligands.
作者信息
Catarzi D, Cecchi L, Filacchioni G, Bartolini A, Carpenedo R, Galli A, Mori F
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Firenze, Italy.
出版信息
Drug Des Discov. 1993;10(1):23-34.
PMID:8399992
Abstract
The synthesis and the GABAA binding activity of a series of 1-amino-2-alkylphthalazinium bromides (series A) and 1-amino-3-alkylphthalazinium bromides (series B) bearing different substituents at position-4 are reported. Some compounds of series A, bearing a lipophilic substituent at position-4, showed a good binding activity as well as in vivo convulsant activity.
摘要
Zotero 插件