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[兔实验性肾缺血性动脉高血压中左右心室对体循环动脉压长期升高反应差异的评估]

[An assessment of the differences in the reaction of the left and right heart ventricles to a long-term rise in systemic arterial pressure in experimental renoprival arterial hypertension in rabbits].

作者信息

Frolov V A, Drozdova G A, Kazanskaia T A, Ramdavon P

出版信息

Biull Eksp Biol Med. 1993 Jul;116(7):21-3.

PMID:8400167
Abstract

Different parameters of the function of the left and right heart ventricles were investigated in rabbits with renoprival arterial hypertension during a period of 52 weeks from the moment of modelling the process. As a result, this process was divided into 3 stages: 1. The establishment of compensation (1-4 weeks); 2. Compensation (6-10 weeks); 3. Decompensation (22-52 weeks). In mathematical prognosis of the time-course changes in the parameters associated with different stages of the process, the prognostic data were shown to be close to the experimental ones during prognosis for the left ventricle in the second stage, and for the right ventricle in the first stage. While prognosing for the left ventricle in the first stage and for the right ventricle in the second stage, the data obtained were significantly different from the experimental ones. These results suggest a conclusion that the right ventricle adapts itself to cardiac overload quicker than the left ventricle, but it also gets "worn out" quicker than the latter due to the conditions of "rigid" functioning in the second stage of the process when the adaptive potentials of the heart are limited.

摘要

在从建模过程开始的52周内,对肾缺血性动脉高血压家兔的左右心室功能的不同参数进行了研究。结果,该过程分为3个阶段:1. 代偿建立期(1-4周);2. 代偿期(6-10周);3. 失代偿期(22-52周)。在对与该过程不同阶段相关参数的时间进程变化进行数学预测时,在对第二阶段的左心室和第一阶段的右心室进行预测时,预测数据显示与实验数据接近。而在对第一阶段的左心室和第二阶段的右心室进行预测时,获得的数据与实验数据有显著差异。这些结果得出一个结论,即右心室比左心室更快地适应心脏超负荷,但由于在该过程第二阶段“刚性”功能的条件下心脏的适应潜力有限,它也比左心室更快地“耗竭”。

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