Osadchiĭ O E, Pokrovskiĭ V M, Cherednik I L, Kurzanov A N
Biull Eksp Biol Med. 1993 Jul;116(7):4-6.
The ranges of the controlled bradycardia were obtained in experimental anaesthetized cats when peripheral cut end of the right vagus nerve was stimulated with bursts of impulses. Within the range each burst of impulses delivered on the vagus induced a single heart contraction and the heart synchronously reproduced any changes of vagal burst frequency. Sinus arrhythmia was observed when vagal burst frequency was beyond the limits of the controlled bradycardia range. Sinus arrhythmia discontinued or considerably decreased after met-enkephalin injection that contributed to the appearance of controlled bradycardia again. It is concluded that met-enkephalin increased the susceptibility of the heart to the series of vagal bursts arriving from the central nervous system.
在实验性麻醉猫中，当用脉冲串刺激右侧迷走神经的外周切断端时，获得了可控性心动过缓的范围。在此范围内，施加于迷走神经的每一串脉冲都会诱发一次心脏收缩，并且心脏会同步再现迷走神经脉冲频率的任何变化。当迷走神经脉冲频率超出可控性心动过缓范围的极限时，会观察到窦性心律失常。注射甲硫氨酸脑啡肽后，窦性心律失常停止或显著减轻，这再次促成了可控性心动过缓的出现。得出的结论是，甲硫氨酸脑啡肽增加了心脏对从中枢神经系统传来的一系列迷走神经脉冲的敏感性。
