Bergeron R, Streiff R R, King W, Daniels R D, Wiegand J
Department of Medicinal Chemistry, University of Florida, Gainesville 32610.
Blood. 1993 Oct 15;82(8):2552-7.
A comparative study of the iron-clearing properties of subcutaneously administered desferrioxamine and parabactin is presented. The evaluation was performed in both a non-iron-overloaded bile-duct cannulated rat and an iron-loaded Cebus monkey model. Parabactin was superior to desferrioxamine in both the rodent and the primate. Unlike desferrioxamine, nearly all of the parabactin-induced iron clearance occurred in the bile. This study represents an evaluation of the iron-clearing properties of parabactin, a hexacoordinate catecholamide siderophore.
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