Radu D, Huljic P, Hewel T, Knetsch E
Med Klin. 1977 Feb 22;Spec No:suppl 25-8.
Interested by a comparative trial on tetracycline concentrations in gallbladder, bile and peritoneum 3 hours after administration, we wanted to know the long-term tissue concentrations, measured towards the end of a 24-hour off-drug interval, as these concentrations are particularly important for a bacteriostatic drug. We found that the tissue concentrations of doxycycline in gallbladder wall, lung, muscle, and thyroid gland were 2 to 3 times higher than those of pyrrolidino-methyltetracycline. The concentrations in the skin, in various sections of the intestinal tract and of the peritoneum, and in the gallbladder content were about the same for both drugs. The implications of these data for therapy are discussed.
我们对给药3小时后胆囊、胆汁和腹膜中的四环素浓度比较试验感兴趣，想了解在24小时停药间隔结束时测得的长期组织浓度，因为这些浓度对于抑菌药物尤为重要。我们发现，强力霉素在胆囊壁、肺、肌肉和甲状腺中的组织浓度比吡咯烷甲基四环素高2至3倍。两种药物在皮肤、肠道各段、腹膜以及胆囊内容物中的浓度大致相同。本文讨论了这些数据对治疗的意义。
