Burger R, Schmehe G, Strothmann G, Engelhardt K
Med Klin. 1977 Jan 7;72(1):21-7.
Prospective research showed that unwanted side-effects resulting from medical therapy were found in 20,6% of all patients hospitalized in our medical clinic during a period of one year. Part of these side-effects was considered a possible reason for admission to the hospital and a cause of complications during the clinical treatment. The side-effects were classified according to their severity, duration, symptomatology and pathogenesis. Furthermore, the frequency of side-effects was studied with regard to age, sex and groups of drugs. It was possible to predict about 80% of the side-effects by considering pharmacological properties and individual risk-factors. The careful integration of these criteria into the treatment plan and the observation of the course of the disease is the basis for calculating the probability of occurrence of side-effects.
前瞻性研究表明，在我们医疗诊所住院的所有患者中，有20.6%在一年期间出现了药物治疗产生的不良副作用。这些副作用的一部分被认为是入院的可能原因以及临床治疗期间并发症的起因。根据副作用的严重程度、持续时间、症状和发病机制对其进行了分类。此外，还针对年龄、性别和药物类别研究了副作用的发生频率。通过考虑药理特性和个体风险因素，可以预测约80%的副作用。将这些标准仔细纳入治疗计划并观察疾病进程是计算副作用发生概率的基础。
