[Investigations of the clinical course of acute myocardial infarction. I. The fibrinolytic treatment of acute myocardial infarction with streptokinase (author's transl)].

In 26 hospitals a study was carried out to investigate the influence of fibrinolytic therapy on mortality in hospital in acute myocardial infarction. The study was concerned with the question whether fibrinolytic therapy in acute myocardial infarction could lower the hospital mortality and whether fibrinolytic therapy should be recommended as an additional therapy for any type of hospital, irrespective individual differences in treatment. 483 out of 1463 patients were treated with streptokinase. These patients were randomized in two groups. Group I was treated in the usual way additionally streptokinase was given, group II without streptokinase. Both groups were similar regarding the course of illness and clinical data. It could be shown that the mortality was not significantly lowered by streptokinase. But in case of shock the mortality seemed to be lower after streptokinase, this difference not being significant.