Bode J C, Schmidt U, Dürr H K
Med Klin. 1977 Mar 25;72(12):513-8.
Silymarin has been claimed to have a benificial effect in various types of liver injury. In a prospective study in patients with acute viral hepatitis (n = 151) the effectiveness of this drug on the cause of the disease was tested. The groups with and without Silymarin (Legalon) were comparable concerning age and sex distribution and the frequency of HBs-antigen positive hepatitis; Laboratory findings (total serum bilirubin, activity of GOT, GPT and alkaline phosphatase and prothrombin time) were determined in intervals of 5 to 7 days over a period of 5 weeks beginning with the onset of jaundice. There were no statistical significant differences between both groups in the decrease of mean values of all parameters tested. The frequency of nearly normalized values of transaminases and serum bilirubin after 10, 20 and 30 days was not higher in the group treated with Silymarin as compared to the controls. It is concluded that Silymarin has no favourable effects on the cause of acute viral hepatitis.
水飞蓟素据称对各种类型的肝损伤都有有益作用。在一项针对急性病毒性肝炎患者（n = 151）的前瞻性研究中，对这种药物对病因的疗效进行了测试。使用和未使用水飞蓟素（利加隆）的两组在年龄、性别分布以及乙肝表面抗原阳性肝炎的发生率方面具有可比性；从黄疸出现开始，在5周的时间里，每隔5至7天测定一次实验室检查结果（血清总胆红素、谷草转氨酶、谷丙转氨酶和碱性磷酸酶的活性以及凝血酶原时间）。在所有测试参数的平均值下降方面，两组之间没有统计学上的显著差异。与对照组相比，使用水飞蓟素治疗的组在10天、20天和30天后转氨酶和血清胆红素接近正常水平的频率并不更高。得出的结论是，水飞蓟素对急性病毒性肝炎的病因没有有利影响。
