Schaefer K, von Herrath D, Hensel A, Grigoleit H G
Med Klin. 1977 Feb 11;72(6):204-6.
The pharmacokinetical behaviour of 14C-labelled pentoxifylline was investigated in normal volunteers and in patients with different stages of impaired renal function. It was shown that in patients, having a creatinine-clearance of less than 10,0 ml/min., occurs an accumulation of pentoxifylline. This finding leads to the conclusion that in patients with advanced renal failure the daily dose of pentoxifylline should be adjusted to the diminished renal elimination.
在正常志愿者和不同肾功能受损阶段的患者中研究了14C标记的己酮可可碱的药代动力学行为。结果表明，肌酐清除率低于10.0 ml/min的患者中会出现己酮可可碱蓄积。这一发现得出结论，在晚期肾衰竭患者中，己酮可可碱的每日剂量应根据肾脏清除率降低的情况进行调整。
