Sofikitis N, Miyagawa I
Tottori University School of Medicine, Department of Urology, Yonago, Japan.
Int J Fertil Menopausal Stud. 1993 Jul-Aug;38(4):250-5.
To evaluate the importance of retrograde adrenal metabolite flow for testicular function in a varicocelized animal model.
Partial occlusion of the left renal vein and ligation of the collateral vein between the left testicular and left common iliac veins was carried out on 14 Wistar rats (group A); same procedure plus adrenalectomy on 14 others (group B); seven sham operated (C) and seven with adrenalectomy alone (D).
Groups A and B showed significant reduction in fertility, and also bilaterally in difference between testicular and abdominal temperatures, epididymal spermatozoal content and motility, and testicular weight at 12 weeks post-surgery. All values were nearly identical in groups A and B.
Since left adrenalectomy did not ameliorate the effects of varicocele, it appears that retrograde flow of adrenal metabolite(s) may not be responsible for the harmful effect of (left) varicocele on fertility.
在精索静脉曲张动物模型中评估肾上腺代谢产物逆行流动对睾丸功能的重要性。
对14只Wistar大鼠（A组）进行左肾静脉部分闭塞以及左睾丸静脉与左髂总静脉之间的侧支静脉结扎；对另外14只大鼠（B组）进行相同操作并加做肾上腺切除术；7只大鼠进行假手术（C组），7只大鼠仅行肾上腺切除术（D组）。
A组和B组在术后12周时生育力显著降低，且双侧睾丸与腹部温度差异、附睾精子含量及活力以及睾丸重量均有显著下降。A组和B组的所有数值几乎相同。
由于左肾上腺切除术并未改善精索静脉曲张的影响，因此肾上腺代谢产物的逆行流动似乎并非（左侧）精索静脉曲张对生育力产生有害影响的原因。
