Mroczka J, Bilski R, Dziaduś-Sokołowska A, Szlachcic A, Sieppel-Maciejewska K, Michalski J
Department of Biophysics, Medical Academy, Kraków, Poland.
Pol J Pharmacol. 1993 Jan-Feb;45(1):67-74.
The aim of this study was to establish whether some psychotropic drugs, applied to patients under influence of alcohol, may potentiate its damaging action on gastric mucosal barrier. A sensitive index of such damage is a decline of the potential difference (PD) across the stomach wall. The experiments were carried out on Wistar rats of either sex, anesthetized with urethane-chloralose. The PD values were assayed with an apolarization method. The investigated solutions were administered intragastrically by gavage. Ethanol at a concentration of 40% v/v depressed PD by 39%. The investigated psychotropic drugs did not change PD by themselves but given in combination with ethanol caused significant decline of PD: diazepam (0.4 mg/kg) by 58%, chlorpromazine (6.7 mg/kg) by 59%, imipramine (2 mg/kg) by 48%, amitriptyline (4 mg/kg) by 49%, phenytoin (4 mg/kg) by 53%, pyridinol (0.3 mg/kg) by 58%. Intragastric administration of water did not change PD. The results indicate that while psychotropic drugs given alone do not affect significantly the gastric mucosal barrier, they may potentiate the damaging action of ethanol on this barrier.
本研究的目的是确定某些精神药物应用于受酒精影响的患者时，是否会增强酒精对胃黏膜屏障的损害作用。这种损害的一个敏感指标是胃壁跨膜电位差（PD）的下降。实验在使用乌拉坦-氯醛糖麻醉的Wistar大鼠（雌雄不限）身上进行。PD值采用非极化方法测定。研究溶液通过灌胃法经胃内给药。浓度为40%（v/v）的乙醇使PD降低了39%。所研究的精神药物本身不会改变PD，但与乙醇联合使用会导致PD显著下降：地西泮（0.4mg/kg）使PD下降58%，氯丙嗪（6.7mg/kg）使PD下降59%，丙咪嗪（2mg/kg）使PD下降48%，阿米替林（4mg/kg）使PD下降49%，苯妥英（4mg/kg）使PD下降53%，吡啶醇（0.3mg/kg）使PD下降58%。经胃内给予水不会改变PD。结果表明，虽然单独使用精神药物对胃黏膜屏障没有显著影响，但它们可能会增强乙醇对该屏障的损害作用。
