电惊厥治疗期间钙通道阻滞对大鼠大脑皮质肾上腺素能受体亚群的影响。
The effect of calcium channel blockade during electroconvulsive treatment on cerebral cortical adrenoceptor subpopulations in the rat.
作者信息
Antkiewicz-Michaluk L, Michaluk J, Romańska I, Vetulani J
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
出版信息
Pol J Pharmacol. 1993 Mar-Apr;45(2):197-200.
PMID:8401773
Abstract
Chronic administration of nifedipine (5 mg/kg/day for 10 days) induced some biochemical effects consistent with those of antidepressants: a significant depression in cortical alpha 2-adrenoceptor density and reduction of beta-adrenoceptor affinity; nifedipine co-administration with electroconvulsive treatment potentiated the beta-downregulatory effect of the latter.
摘要
硝苯地平长期给药（5毫克/千克/天，持续10天）可引发一些与抗抑郁药相符的生化效应：皮质α2-肾上腺素能受体密度显著降低，β-肾上腺素能受体亲和力下降；硝苯地平与电休克治疗联合使用可增强后者的β-下调效应。
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