Goodyer I, Cooper P J
Section of Developmental Psychiatry, Cambridge.
Br J Psychiatry. 1993 Sep;163:374-80. doi: 10.1192/bjp.163.3.374.
The clinical characteristics of two subsamples of 11-16-year-old girls were determined from direct interview: those who met DSM-III-R criteria for an episode of major depressive disorder within the past month (n = 28); and those who did not currently meet these criteria but had done so at some time in the previous 12 months (n = 13). The symptom profiles of these cases were compared with a subsample of girls who reported depressive symptoms but did not meet DSM-III-R criteria and were designated as having a 'partial syndrome' (n = 93), and a sample of non-depressed controls (n = 129). Phobias and worry about peer acceptance were common in controls suggesting that these symptoms constitute normal adolescent concerns. The symptom profile of depressed cases altered across three age bands (11-12, 13-14, and 15-16 years), suggesting developmental influences on clinical presentation. Comorbidity for anxiety, behavioural, and obsessional disorders was found in 40% of the depressed cases. None of the cases of major depressive disorder was known to the clinical services.
通过直接访谈确定了两个11至16岁女孩子样本的临床特征:在过去一个月内符合《精神疾病诊断与统计手册》第三版修订版(DSM-III-R)中重度抑郁症发作标准的女孩(n = 28);以及目前不符合这些标准但在过去12个月内曾符合标准的女孩(n = 13)。将这些病例的症状概况与报告有抑郁症状但不符合DSM-III-R标准并被认定为患有“部分综合征”的女孩子样本(n = 93)以及非抑郁对照组样本(n = 129)进行了比较。恐惧症和对同伴接纳的担忧在对照组中很常见,这表明这些症状是青少年正常的关注点。抑郁病例的症状概况在三个年龄组(11至12岁、13至14岁和15至16岁)中有所变化,表明发育对临床表现有影响。40%的抑郁病例存在焦虑症合并行为和强迫性障碍。临床服务机构均不了解重度抑郁症的任何病例。