Kuzelová M, Svec P
Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Cesk Farm. 1993 Jun;42(3):124-6.
The effect of the blockers of calcium channels on the development of myocardial ischaemia in rats with an occlusion of the coronary artery was examined. An occlusion of the coronary artery was carried out in rats anaesthetized with pentobarbital by tightening the ends of the ligature freely placed under the left coronary artery - ramus interventricularis seven days prior to ligation. The ischaemia-induced changes in the R-wave and ST-segment were recorded using ECG. The occlusion of the coronary artery produced arrhythmias, a significant elevation of the ST-segment and a slight increase in the heart rate. The blockers of calcium channels with different pharmacological properties - verapamil, nifedipine and diltiazem influenced the ischaemia-induced changes with different intensity. Nifedipine (0.02 mg.kg-1, i.v., 30 min prior to occlusion), verapamil (0.2 mg.kg-1, i.v., 10 mins prior to ischaemia), and diltiazem (0.3 mg.kg-1, i.v., 10 mins prior to ischemia) significantly reduced the increased elevation of the ST-segment. The highest effect on the above-mentioned model was shown by verapamil.
研究了钙通道阻滞剂对冠状动脉闭塞大鼠心肌缺血发展的影响。在结扎前7天，通过收紧自由放置在左冠状动脉 - 室间支下方的结扎线末端，对用戊巴比妥麻醉的大鼠进行冠状动脉闭塞。使用心电图记录缺血诱导的R波和ST段变化。冠状动脉闭塞导致心律失常、ST段显著升高和心率略有增加。具有不同药理特性的钙通道阻滞剂 - 维拉帕米、硝苯地平和地尔硫䓬对缺血诱导的变化有不同程度的影响。硝苯地平（0.02 mg.kg-1，静脉注射，闭塞前30分钟）、维拉帕米（0.2 mg.kg-1，静脉注射，缺血前10分钟）和地尔硫䓬（0.3 mg.kg-1，静脉注射，缺血前10分钟）显著降低了ST段升高的幅度。维拉帕米对上述模型的效果最为显著。
