[水合（二乙酰氧基苯甲酸酯）铜配合物的解热活性]
[Anti-pyretic activity of aqua-(diacetoxybenoate)-copper complexes].
作者信息
Sokolík J, Tumová I, Lucanská B, Blahová M, Svec P
机构信息
Katedra chemickej teórie lieciv a Katedra farmakológie a toxikológie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
出版信息
Cesk Farm. 1993 Aug;42(4):188-90.
The antipyretic activity of binuclear (diacetoxybenzoato)-copper(II) aquacomplexes [Cu2(2,Y-DAB)4(H2O)2] (Y = 4 and 5) as well as cupric acetylsalicylate [Cu2(AcSal)4] was assayed in a rabbit model of endotoxin-induced fever. The complexes and uncomplexed carboxylic acids (administered i.p. in a dose of 20 mg/kg) exhibited even a subnormothermic course in lowering of febrile animals' body temperature in the order: 2,5-diacetoxybenzoic acid (-0.09 degree C) < 2,4-diacetoxybenzoic acid (-0.35 degree C) < Cu(AcSal)2(-0.39 degree C) approximately equal to acetylsalicylic acid (-0.40 degree C) < Cu(2,4-DAB)2.H2O (-0.61 degree C) < Cu(2.5-DAB)2.H2O (-0.97 degree C). On the other hand, the mean value of untreated fevered animals was +0.67 degree C.
在兔内毒素诱导发热模型中测定了双核（二乙酰氧基苯甲酸根）-铜（II）水配合物[Cu2(2,Y-DAB)4(H2O)2]（Y = 4和5）以及乙酰水杨酸铜[Cu2(AcSal)4]的解热活性。这些配合物和未配位的羧酸（腹腔注射剂量为20 mg/kg）在降低发热动物体温方面呈现出亚正常体温过程，顺序为：2,5-二乙酰氧基苯甲酸（-0.09℃）< 2,4-二乙酰氧基苯甲酸（-0.35℃）< Cu(AcSal)2（-0.39℃）≈乙酰水杨酸（-0.40℃）< Cu(2,4-DAB)2·H2O（-0.61℃）< Cu(2.5-DAB)2·H2O（-0.97℃）。另一方面，未治疗的发热动物的平均值为+0.67℃。
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