Takeuchi Y, Yasukawa H, Yamaoka Y, Takahashi N, Tamura C, Morimoto Y, Fukushima S, Vasavada R C
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
Chem Pharm Bull (Tokyo). 1993 Aug;41(8):1434-7. doi: 10.1248/cpb.41.1434.
Fourie transform infrared/attenuated total reflection analysis demonstrated that the absorbance intensity of C = O stretching bands, which reflect the amounts of lipids in the stratum corneum, decreased with an increase in the duration of skin treatment with 0.15 M oleic acid/propylene glycol (PG) system, suggesting that the oleic acid/PG system induced the lipid extraction, which was followed by a reorganization of the stratum corneum structures. The spectral peaks which originated from the PG molecule were detected in dermal tissues after 30 min of treatment of the stratum corneum with the same system. This observation suggested that the reorganization of the lipid domains due to the lipid extraction by the oleic acid/PG system helped the PG molecules enter the dermal tissues. It was also suggested that an effective volume within the stratum corneum for solutes and/or solvents which could penetrate through the inter-, and/or intracellular routes could be altered in conjunction with the structural changes of the lipids.
傅里叶变换红外/衰减全反射分析表明,反映角质层脂质含量的C = O伸缩带的吸光度强度,随着用0.15 M油酸/丙二醇(PG)体系进行皮肤处理时间的增加而降低,这表明油酸/PG体系诱导了脂质提取,随后角质层结构发生了重组。在用同一体系处理角质层30分钟后,在真皮组织中检测到了源自PG分子的光谱峰。这一观察结果表明,油酸/PG体系提取脂质导致脂质域的重组,有助于PG分子进入真皮组织。还表明,角质层内溶质和/或溶剂可通过细胞间和/或细胞内途径渗透的有效体积,可能会随着脂质结构的变化而改变。